Endometrial Biopsy – What you should know

Important things to know

  1. We recommend that you take 800mg – 1000 mg of ibuprofen with some food 1 hour prior to your endometrial biopsy to reduce discomfort. If you are unsure if this is safe for you please contact us.
  2. If you are still having periods(and not in menopause), please read the section below. it is important to rule out pregnancy prior to your biopsy.

You must be within 7 days of the start of your normal menstrual period or have     not had intercourse since the start of your last normal period.


You have not had unprotected intercourse for 12 days prior to your appointment(100% use of condoms or hormonal/reliable birth control) and have a      blood pregnancy test 24-48 hours before your appointment. Withdrawal is not        considered reliable birth control. Discontinue biotin 48 hours before your blood            test. Biotin can be found in many supplements and natural health food products.

  1. If you are still having periods it is not ideal to do the biopsy when you have heavy bleeding. The best time is before your expected period but it is not mandatory.

Why do I need an endometrial biopsy?

 An endometrial biopsy is performed to evaluate the uterine lining for the presence of cancer or precancerous cells. Most women who have this procedure done have abnormal uterine bleeding or an abnormal finding on their ultrasound.

How is it done:

 An endometrial biopsy is a safe and effective method for evaluating the tissue lining inside the uterus. A plastic catheter is slipped into the uterus and some of the lining is sucked into the catheter.

Is an endometrial biopsy painful?

It is uncomfortable for most people. The placement and movement of the thin plastic catheter can produce cramping and the ibuprofen you take before the procedure will help. The procedure takes only a few minutes and most women tolerate it well.

What complications may develop after endometrial biopsy?

You may experience vaginal bleeding for a few days following the procedure. It is important to rule out pregnancy because a pregnancy can be affected by the procedure. An infection or a perforation (if the catheter makes a small hole in the wall of the uterus) are very rare.

What happens to the sample that is removed from the lining of my uterus:

The cells from the tissue in the sample will be looked at under a microscope by a pathologist. Our office will contact you with the results. this can take up to 3 weeks.

Following Endometrial Biopsy

  1. If you have any discomfort after the procedure you may take ibuprofen 400mg every 6- 8 hours as needed. Acetaminophen can also be taken but is not as effective.
  2. Some vaginal bleeding or spotting is common following the procedure and can last up to a week. If you experience worrisome heavy bleeding please contact us.
  3. Infection is uncommon but if you experience ongoing pain, fever or foul smelling discharge please contact the clinic.
  4. Please do not place anything in your vagina and avoid sex, hot tubs, pools and baths for 48 hours